Enhesa GHS+ Chemical Hazard Assessment framework overview

Learn how we generate and maintain Chemical Hazard Assessments (CHAs)—including the process steps, data requirements, evaluation criteria, and assessor qualifications.

Introduction

Since SciveraLENS’s founding in 2008, our toxicologists have performed comprehensive chemical hazard assessments using procedures and criteria established by government authorities, accreditation bodies, and widely accepted toxicology practices.

This page outlines the steps, data requirements, evaluation criteria, and assessor qualifications used by the Enhesa Sustainable Chemistry team to generate and maintain a Chemical Hazard Assessment (CHA). These assessments evaluate the human and environmental health characteristics of industrial chemicals.

🧪 Hazard Assessment Overview

Our toxicologists follow a structured process that:

  • Confirms the identity of the chemical under assessment

  • Screens the chemical against authoritative and regulatory lists to identify early indicators of potential concern

  • Assesses hazard characteristics across 24 human and environmental health endpoints, plus relevant physical hazard endpoints

  • Determines an overall hazard category for the chemical, integrating list reviews and endpoint assessment results

Figure 1-1: SciveraLENS GHS+ Chemical Hazard Assessment Process Flow Diagram

 

We’ve built and updated the GHS+ Chemical Hazard Assessment Process (“GHS+”) on a foundation of the broadly-accepted approach, endpoints, and criteria from the following leading documented references for best practices in this discipline:

💡 Reference Foundations for GHS+

Enhesa GHS+ Chemical Hazard Assessment Process

Enhesa Sustainable Chemistry’s GHS+ process ensures a thorough and scientifically grounded Chemical Hazard Assessment (CHA). The steps below outline our standardized approach.


Step 1 – Confirm Chemical Identity

Step 1 – Confirm Chemical Identity

To begin a CHA, our toxicologists first verify the identity of the chemical using a set of accepted methods. This step ensures a reliable connection between the substance and its relevant data across physical-chemical, human health, and environmental endpoints.

Primary Identifier:

  • CAS RN (Chemical Abstract Service Registry Number): The most widely used unique identifier, linking chemicals to data. While there are over 279 million CAS RNs, we focus on the ~400,000 relevant to consumer products and industrial applications in our SciveraLENS Chemical Data Repository.

Other Identifiers (if CAS RN is missing or conflicting):

  • EC Number (ECHA)
  • US EPA PMN (Pre-Manufacture Notification Number)
  • SMILES notation (molecular structure)
  • Other authoritative references

Why This Matters:

  • Accurate chemical identification ensures compatibility with regulatory lists, minimizes ambiguity from naming conventions, and supports the use of modeling tools and analog analysis.

Step 2 – Screen Against Chemical Lists

Step 2 – Screen Against Chemical Lists

Next, we screen the chemical against a curated collection of 600+ lists within SciveraLENS, organized into:

  • Regulatory Lists
  • Authoritative Lists
  • Restricted Substance Lists (RSLs)
  • Screening & Watch Lists
  • Preferred & Organizational Lists
  • Chemical Groups
  • Informational/Inventory Lists

These lists help identify initial indications of concern for human or environmental health endpoints.

Important Note: List screening is not equivalent to a full hazard assessment. While helpful for early prioritization, only a full assessment can determine the true hazard profile.

Chemical Groups: Many lists flag groups of chemicals (e.g., “mercury and its compounds”) rather than individual substances. Our team maps group listings to specific chemicals—a complex but essential task to provide clarity for users.


Step 3 – Endpoint-Level Hazard Assessment

Step 3 – Endpoint-Level Hazard Assessment

Toxicologists assess each endpoint using multiple data types:

  • Authoritative Lists
  • Regulatory Lists
  • Experimental Data
  • Modeled Data
  • Analogous Data
  • Expert Judgment

Data Sources Include:

  • NIH/NLM (e.g., PubChem)
  • ECHA REACH dossiers
  • US EPA databases
  • NTP reports
  • IARC monographs
  • ToxPlanet
  • Peer-reviewed literature

Modeling Tools:

  • OECD QSAR Toolbox
  • US EPA EpiSuite
  • US EPA T.E.S.T.
  • PBT Profiler (referenced but no longer supported)

Best Practices:

  • Analog Read-Across: Used when direct data is missing.
  • Expert Judgment: Toxicologists assess data quality and consistency.
  • Data Reliability: High-quality experimental data is preferred. Klimisch scores and other indicators are used, but expert review is central.
  • Weight-of-Evidence: When data conflict, we apply a precautionary principle, classifying at the highest supported hazard level.

🧪 Endpoints Assessed in the GHS+ Chemical Hazard Assessment

We evaluate three endpoint categories: Human Health, Environmental Health, and Physical-Chemical Properties. Each includes Core and Supplemental endpoints.

🧍‍♀️ Human Health Endpoints

✅ Core Endpoints

Required for an overall hazard category other than “Gray” (i.e., insufficient data):

  • Carcinogenicity
  • Mutagenicity / Genotoxicity
  • Developmental Toxicity
  • Reproductive Toxicity
  • Endocrine Activity

➕ Supplemental Endpoints

Contribute to the hazard profile; data gaps are permitted:

  • Acute Oral Toxicity
  • Acute Dermal Toxicity
  • Acute Inhalation Toxicity
  • Respiratory Sensitization
  • Dermal Sensitization
  • Dermal Irritation
  • Eye Irritation
  • Systemic Toxicity (Single and Repeat Dose)
  • Neurotoxicity (Single and Repeat Dose)
  • Sensory Irritation
  • Aspiration Potential

🔎 To avoid a “Gray” score, all Core Human Health Endpoints must be conclusively assessed. Supplemental endpoints support the overall picture but are not mandatory for a conclusive score.


🌿 Environmental Health Endpoints

✅ Core Endpoints

Required for a conclusive overall environmental hazard category:

  • Persistence
  • Bioaccumulation
  • Acute or Chronic Aquatic Toxicity

➕ Supplemental Endpoint

  • Mobility (assessed and documented; not factored into scoring)

🔎 To avoid a “Gray” score, data must be conclusive for Persistence, Bioaccumulation, and at least one aquatic toxicity endpoint.


🔥 Supplemental Physical-Chemical Endpoints

Assessed when relevant and data are available:

  • Flammability
  • Reactivity
  • Environmental Transformation Products

⚠️ If a transformation product is persistent, bioaccumulative, or toxic, it may affect the scoring of related endpoints like Persistence or Toxicity.


🚦 Hazard Communication: The GHS+ Traffic Light System

Each endpoint and overall hazard assessment is communicated using a color-coded system. This process ensures our partners and stakeholders receive transparent, science-driven insight into chemical hazards, supporting safer and more sustainable decision-making.

📊 Table 2-1: SciveraLENS GHS+ Endpoint-Level Hazard Assessment Conditions

Color Code Hazard Level Meaning
🟢 Green Low Hazard Indicates a low hazard for the specific endpoint or overall chemical.
🟡 Yellow Moderate Hazard Indicates a moderate hazard.
🔴 Red High Hazard Indicates a high hazard.
⚫ Black Very High Hazard Indicates a very high hazard.
⚪ Gray Insufficient Data Data are insufficient for assessment.
🔵 Blue Assessment in Progress No concerns found during list screening; assessment not yet complete.
◑ Half-Gray Modeled/Analog Data Indicates use of modeled, analogous, or expert judgment data in the score.

🔎 This traffic light system provides a clear, intuitive way to interpret chemical hazard assessments at both the endpoint and overall level.

🧮 Step 4 – Overall Chemical Hazard Categorization

While individual endpoint results provide detailed insight into hazard type and severity, an overall hazard category enables efficient comparison, prioritization, and alternatives assessment.

To assign this category, Enhesa Sustainable Chemistry uses a rules-based system implemented in SciveraLENS. The system evaluates all endpoint-level assessments to determine the Overall Hazard Category.


Step 4 – Overall Chemical Hazard Categorization

📊 SciveraLENS Overall Chemical Hazard Categories and Rules

Category Criteria
🟢 Green – Highly Preferred – All endpoints show conclusive or limited-evidence low hazard
– No data gaps for Core or Supplemental Endpoints
🟢🟡 Green/Yellow – Preferred – All Human Health Core Endpoints are low hazard with no data gaps
– One or more Supplemental Endpoints are moderate hazard
– One Environmental Fate Endpoint may be high if others are low
– No endpoints show very high hazard
– No more than three Supplemental data gaps
🟡 Yellow – Acceptable – One or more Supplemental Endpoints are high or very high hazard
No Core Endpoints are high or very high hazard
No Environmental Fate Endpoints are high if paired with moderate Human Health or Ecotoxicity hazards
– No more than three Supplemental data gaps
No Core data gaps
🔴 Red – High Concern – One or more Human Health Core Endpoints are high or very high hazard, or
– Two or more Environmental Health Core Endpoints are high or very high hazard (e.g., Persistence + Bioaccumulation), or
Very High Persistence or Bioaccumulation combined with very high acute or high chronic Human Health hazards
Gray – Unable to Categorize – One or more Core Endpoint data gaps, or
– Four or more Supplemental Endpoint data gaps
🔵 Blue – In Process – Assessment not yet complete

Step 5 – Quality Assurance & Verification

🛡️ Step 5 – Enhesa Sustainable Chemistry Quality Assurance & Verification

GHS+ hazard assessments are completed within our Chemical Data Repository (CDR), the engine behind SciveraLENS. Key QA features include:

  • Quantitative scoring integration for endpoints like acute and aquatic toxicity

  • 📚 Source tracking to document all reviewed references

  • 🔄 Workflow stages based on endpoint types (e.g., CMRD, PBT) and status (Research → Assess → QA → Complete)

  • 👥 Dual review process: A board-certified toxicologist performs a full second review before finalization

🔎 Once verified, the hazard assessment is marked “Complete” and fully aligned with the GHS+ framework.

Enhesa Sustainable Chemistry continuously improves the GHS+ methodology by engaging external board-certified toxicologists and scientific authorities, ensuring the framework evolves with new science and stakeholder input.


Step 6 – Ongoing Maintenance

🔄 Step 6 – Ongoing Maintenance of GHS+ Hazard Assessments

Hazard assessments are actively maintained through a structured, recurring update process:

  • 🗂️ List monitoring and updates propagate automatically across affected chemicals

  • 🔬 New hazard data is evaluated and used to revise endpoint scores

  • 🔔 User alerts notify SciveraLENS users of changes to chemicals of interest

📅 The GHS+ framework is a living system, designed to stay up-to-date with the latest data and scientific consensus.

References

📚 3. References

Appendix A: SciveraLENS GHS+ Chemical Hazard Assessment Framework – Criteria by Endpoint

SciveraLENS GHS+ Chemical Hazard Assessment Framework – Criteria by Endpoint

Human Health Endpoints – Chronic

Hazard GHS+ Criteria Very High High Moderate Low
Carcinogenicity GHS GHS Category 1A – Known human carcinogen (largely based on human evidence) GHS Category 1B – Presumed human carcinogen (largely based on animal evidence) GHS Category 2 – Suspected human carcinogen
GHS+ Qualitative Assessment of Available Data Experimental and modeling data may be used. Experimental and modeling data may be used. Experimental and modeling data may be used. Modeling data may not be used alone. Negative modeling with negative Mutagenicity/Genotoxicity and repeated dose Systemic Toxicity.
Mutagenicity/Genotoxicity GHS GHS Category 1A GHS Category 1B GHS Category 2
Known to induce heritable mutations in germ cells of humans Presumed to induce heritable mutations in germ cells of humans. Experimental and modeling data may be used. Suspected of inducing heritable mutations in the germ cells of humans. Experimental and modeling data may be used. Experimental and modeling data may be used. Modeling data may not be used alone.
Authoritative Lists EU Category 1 EU Category 2 EU Category 3
Developmental and Reproductive Toxicity (scored as separate endpoints) GHS GHS Category 1A GHS Category 1B GHS Category 2
Known human reproductive toxicant Presumed human reproductive toxicant Suspected human reproductive toxicant
Assessment of Available Quantitative Data (quantitative values are used for guidance only, considered in the context of maternal toxicity in relation with reproductive / developmental effects) NOAEL/LOAEL oral (mg/kg/day): <50 NOAEL/LOAEL oral (mg/kg/day): 50-250 NOAEL/LOAEL oral (mg/kg/day): >250
NOAEL/LOAEL dermal (mg/kg/day): <100 NOAEL/LOAEL dermal (mg/kg/day): 100-500 NOAEL/LOAEL dermal (mg/kg/day): >500
NOAEL/LOAEL inhalation (vapor/gas) (mg/L/day): <1 NOAEL/LOAEL inhalation (vapor/gas) (mg/L/day): 1-2.5 NOAEL/LOAEL inhalation (vapor/gas) (mg/L/day): >2.5
NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/day): <0.1 NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/day): 0.1-0.5 NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/day): >0.5
Qualitative Assessment of Available Data Experimental and modeling data may be used. Experimental and modeling data may be used. Experimental and modeling data may be used. Modeling data may not be used alone
Authoritative Lists EU Category 1 EU Category 2 EU Category 3
California Proposition 65 – listed
Endocrine Activity GHS+ Qualitative Assessment of Available Data Evidence of endocrine disrupting activity in appropriate assays. Evidence or endocrine activity and related human health effect. SVHC endocrine chemicals. When C, D, R and TOST are H and in vivo effect is endocrine-related. Evidence of endocrine activity. When D, R and/or TOST are M with in vivo endocrine-related effects (e.g., thymus, thyroid). Listed on relevant lists; indication of endocrine activity in studies (modeling and in vitro). Modeling indicates “active”. No evidence of activity (no binding, perturbation, or evidence of endocrine-related adverse effects) in appropriate assays and no structural alerts. Need negative data (modeled, in vitro, and in vivo) for key EATS (estrogenic, androgenic, thyroid, steroidogenic) endocrine pathways.
Authoritative Lists EU Category 1 EU Category 2
Hazard Lists ChemSec SIN Listed TEDX Listed

Human Health Endpoints – Acute

Hazard GHS+ Criteria Very High High Moderate Low
Acute Oral Toxicity (LD50, rat) GHS GHS Category 1 or 2 GHS Category 3 GHS Category 4 GHS Category 5 or “not classified”
Qualitative Assessment of Available Data (Experimental or modeled) LD50 ≤ 50 mg/kg 50 mg/kg< LD50 ≤ 300 mg/kg 300 mg/kg < LD50 ≤ 2000 mg/kg LD50 > 2000 mg/kg
Acute Dermal Toxicity (LD50, rabbit) GHS GHS Category 1 and 2 GHS Category 3 GHS Category 4 GHS Category 5 or “not classified”
Qualitative Assessment of Available Data. LD50 ≤ 200 mg/kg 200 mg/kg < LD50 ≤ 1000 mg/kg 1000 mg/kg < LD50 ≤ 2000 mg/kg LD50 > 2000 mg/kg
Acute Inhalation Toxicity (LC50, rat) GHS GHS Category 1 and 2 GHS Category 3 GHS Category 4 GHS Category 5 or “not classified”
Qualitative Assessment of Available Data. Vapor – < 2 mg/L; Dust/mist - LC50 ≤ 0.5 mg/L Vapor- 2 mg/L < LC50 ≤ 10mg/L; Dust/mist - 0.5 mg/L < LC50 ≤ 1.0 mg/L Vapor -10 mg/L < LC50 ≤ 20mg/L; Dust/mist - 1 mg/L < LC50 ≤ 5mg/L Vapor – LC50 > 20 mg/L; Dust/mist LC50 > 5mg/L
Dermal Irritation GHS GHS Category 1, 1A, B and C 2-Irritant 3-Mild irritant “Not Classified”
Qualitative Assessment of Available Data including Modeling Results (e.g., Toxtree “me” data cards) 1A – Evidence of irreversible damage to skin in human following exp of up to 3 min and up to 1 hr observation; or in animal experience or test data; pH extremes of ≤ 2 and ≥ 11.5. 1B,C-Evidence of irreversible damage to skin in human following exp of > 3 min and up to 4 hrs and observations of up to 14 days, or in animal experience or test data; pH extremes of ≤ 2 and ≥ 11.5 — NOTE: If only GHS Category 1 is specified (but not 1A or 1B or 1C) then descriptive data of the hazard will be used to determine score. Evidence of reversible damage to skin following exp of up to 4 hrs (human experience or data or animal experience or data). Modeling data may be used. Evidence of reversible damage to skin following exp of up to 4 hrs in animal experience or test data. Modeling data may be used. Adequate data available, and negative studies, no structural alerts, GHS not classified. Modeling data may not be used alone.
Acute Eye Irritation GHS GHS Category 1 GHS Category 2A GHS Category 2B
Qualitative Assessment of Available Data Damage to the eye which is not fully reversible within 21 days (human data/experience) or positive animal experience or test data in at least 1 animal Changes in the eye which are fully reversible within 21 days (human data/experience) or positive animal experience or test data in at least 2 animals — NOTE: If only GHS Category 2 is specified (but not 2A or 2B) then descriptive data of the hazard will be used to determine score. Modeling data may be used. Evidence of mild eye irritation in human experience or data or animal experience or test data indicating complete reversibility of lesions within 7 d — NOTE: If only GHS Category 2 is specified (but not 2A or 2B) then descriptive data of the hazard will be Adequate data available, and negative studies, no structural alerts, GHS not classified. Modeling data may not be used alone.
Sensory Irritation GHS+ Qualitative Assessment of Available Data RD50 ≤ 5 ppm 5 ppm < RD50 ≤ 1500 ppm RD50 > 1500 ppm
GHS STOT H335

Human Health Endpoints – Other

Hazard GHS+ Criteria Very High High Moderate Low
TOST – Single Exposure (Specific target organ systemic toxicity following single exposure) GHS GHS Category 1 GHS Category 2 GHS Category 3 GHS Category “Not Classified”
Qualitative Assessment of Available Data Reliable evidence of a significant adverse effect on specific organ/systems or systemic toxicity in humans or animals. Oral ≤ 300mg/kg; Dermal ≤ 1000 mg/kg; Inhalation -vapor/gas – ≤ 10 mg/L/4hr; dust/mist/fumes – ≤ 1.0mg/L/4hr Evidence of a harmful adverse effect on specific organ/systems or systemic toxicity from animal studies or humans. Oral – > 300 to ≤ 2000mg/kg; Dermal – > 1000 to ≤ 2000 mg/kg; Inhalation -vapor/gas – > 10 to ≤ 20mg/L/4hr; dust/mist/fume – > 1.0 to ≤ 5.0mg/L/4hr Evidence of transient (1) irritant effects on respiratory tract in humans or (2) transient narcotic effects from animal studies and in humans Adequate data available, and negative studies, no structural alerts, GHS not classified
TOST – Repeat Exposure (Specific target organ systemic toxicity following repeated exposure; based on 90 day exposures) GHS GHS Category 1 GHS Category 2 Not Classified
NOAEL/LOAEL oral (mg/kg/day): <10 NOAEL/LOAEL oral (mg/kg/day): 10-100 NOAEL/LOAEL oral (mg/kg/day): >100
NOAEL/LOAEL dermal (mg/kg/day): <20 NOAEL/LOAEL dermal (mg/kg/day): 20-200 NOAEL/LOAEL dermal (mg/kg/day): >200
NOAEL/LOAEL inhalation (vapor/gas) (mg/L/6h/day): <0.2 NOAEL/LOAEL inhalation (vapor/gas) (mg/L/6h/day): 0.2-1.0 NOAEL/LOAEL inhalation (vapor/gas) (mg/L/6h/day): >1.0
NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/6h/day): <0.02 NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/6h/day): 0.02-0.2 NOAEL/LOAEL inhalation (dust/mist/fume) (mg/L/6h/day): >0.2
Qualitative Assessment of Available Data including Modeling Alerts as needed Reliable evidence of a significant adverse effect on specific organ/systems or systemic toxicity in humans or animals Evidence of a harmful adverse effect on specific organ/systems or systemic toxicity from animal studies or humans. Adequate data available, and negative studies, no structural alerts, GHS not classified. Modeling data may not be used alone.
Aspiration Hazard GHS GHS Category 1 GHS Category 2
Qualitative Assessment of Available Data Human evidence; hydrocarbons with kinematic viscosity of 20.5 mm2/s or less, measured at 40° C Based on animal studies; kinematic viscosity of 14 mm2/s or less, measured at 40°C
Dermal Sensitization GHS GHS Category 1A GHS Category 1B
Substances showing a high frequency of occurrence in humans and/or a high potency in animals Substances showing a low to moderate frequency of occurrence in humans and/or a low to moderate potency in animals
Hazard Lists MAK Sensitizing Substances Sh (Skin) or Sah (Respiratory and Skin)
Qualitative Assessment of Available Data Positive responses in predictive Human Repeat Insult Patch Tests (HRIPT) or other human experience or analogy to chemical classes and/or positive, animal or LLNA data. Modeling data may be used. Modeling data may be used. Adequate data available, and negative studies, no structural alerts, GHS not classified. Modeling data may not be used alone.
Respiratory Sensitization GHS GHS Category 1A GHS Category 1B – Low to moderate sensitization rate in humans or probability thereof based upon animal or other tests
High sensitization rate in humans or probability thereof based upon animal or other tests
Hazard Lists MAK Sensitizing Substances Sa (Respiratory) or Sah (Respiratory and Skin) AOEC
Neurotoxicity See TOST, Single and Repeat see TOST see TOST see TOST
Hazard Lists Listed on Grandjean & Landrigan (ME)
Qualitative Assessment of Available Data Evidence of neurotoxicity in humans or positive results in appropriate animal tests assessing functional observational battery, motor activity, neuropathology Probable human neurotoxicant (some positive results in appropriate animal tests) No evidence for a neurotoxic hazard

Ecotox and E-Fate Endpoints

Hazard GHS+ Criteria Very High High Moderate Low
Eco Toxicity
Acute Hazards to the Aquatic Environment GHS GHS Category 1 GHS Category 2 GHS Category 3 GHS Category “Not Classified”
Qualitative Assessment of Available Data (modeling data may be used) LC/EC50 ≤ 1mg/L (fish 96hr LC50, crustacea 48hr EC/LC50, or aquatic plant 72 or 96hr ErC50). 1 mg/L < LC/EC50 ≤ 10 mg/L (fish 96hr LC50, crustacea 48hr EC/LC50, or aquatic plant 72 or 96hr ErC50) 10 mg/L < LC/EC50 ≤ 100 mg/L (fish 96hr LC50, crustacea 48hr EC/LC50, or aquatic plant 72 or 96hr ErC50) LC/EC50 > 100mg/L
Chronic Hazards to the Aquatic Environment GHS GHS Category 1 GHS Category 2 GHS Category 3 and 4 GHS Category “Not Classified”
Qualitative Assessment of Available Data (modeling data may be used) LC/EC50 ≤ 0.1 mg/L LC/EC50 > 0.1 to ≤ 1mg/L (fish 96hr LC50, crustacea 48hr EC/LC50, or aquatic plant 72 or 96hr ErC50) and BCF ≥ 500 or if absent log Kow ≥ 4 > 1 mg/L 1mg/L. Category 4 – Poorly soluble and no acute toxicity is observed upon water solubility and BCF≥ 500 or if absent log Kow ≥ 4, unless chronic NOECs > 1mg/L LC/EC50 >10 mg/L
Environmental Fate
Persistence Qualitative Assessment of Available Data
% Biodegradation in 28 days ≤10% in 28 days, or when less than 30% in >28 days greater than 10% to <30% in 28 days ≥30% to 70% in 28 days Rapidly degradable; Degradation >70% of dissolved organic carbon in 28 days (reached within a 10-day window); if not available BOD (5 days)/ COD ratio ≥0.5, considered indicative of rapid degradation
Biological Oxygen Demand (BOD)/Chemical Oxygen Demand (COD) ratio BOD (5 day)/COD ratio <0.2, not biodegradable BOD (5 day)/COD ratio 0.2-0.4, slowly biodegradable BOD (5 day)/COD ratio >0.4-0.5, moderately biodegradable BOD (5 day)/COD ratio >0.5, easily biodegradable
t 1/2 in days Persistence in soil or sediment: Half-life>180 days or recalcitrant; Persistence in water: Half-life>60 days or recalcitrant; Persistence in air: >5 days or recalcitrant Soil or Sediment: >60 to 180 days; Water: >40 to 60 days; Air 2 to 5 days Soil or Sediment: 16 to 60 days; Water: 16 to 40 days; Air: Half-life assessed as high or low Soil, Sediment, or Water<16 days; Air<2 days; GHS "Rapid degradability"; Meets 10-day "Ready Biodegradability"
Chemical Class Inorganic – Determined by compound characteristics under environmental conditions
Potential for Long-range Transport Evidence Suggestive Evidence
Potential for Actual Bioaccumulation Qualitative Assessment of Available Data (modeling data may be used) BCF or BAF >5000 or log Kow >5 BCF or BAF >1000 to 5000 or log Kow 4.5-5 BCF or BAF 500 to 1000 or log Kow 4-4.5 BCF or BAF >100 – 500 or log Kow <4.5
Environmental Transformation Products (ETPs)
Environmental Transformation Products (ETPs) Qualitative Assessment of Available Data (modeling data may be used) Experimental data indicating persistent and very highly toxic degradation products. Experimental or modeling data indicating persistent and highly toxic degradation products. Experimental or modeling data indicating persistent and moderately toxic degradation products. Data are available suggesting low concern for ETPs (e.g., low persistence, low toxicity).
Mobility
Mobility Qualitative Assessment of Available Data (modeling data may be used) Log Koc < 2.0 2.0 < Log Koc < 3.0 Log Ko > 3.0

Physical Hazard Endpoints

Hazard GHS+ Criteria Very High High Moderate Low
Flammability GHS: Flammable Liquids GHS Category 1 GHS Category 2 GHS Category 3 and 4 GHS Category “Not Classified”
GHS: Flammable Gases GHS Category 1 GHS Category 2 or GHS Category A GHS Category B or GHS Category “Not Classified”
GHS: Flammable Solids GHS Category 1 GHS Category 1 GHS Category 2 GHS Category 3 or GHS Category “Not Classified”
GHS: Aerosols LC/EC50 ≤ 0.1 mg/L GHS Category 1 GHS Category 2 GHS Category 3 or GHS Category “Not Classified”
GHS: Pyrophoric Liquids GHS Category 1 GHS Category “Not Classified”
GHS: Pyrophoric Solids GHS Category 1 GHS Category “Not Classified”
Qualitative Assessment of Available Data (modeling data may be used) Flashpoint: flammable liquids Flash point < 23 ∘C and initial boiling point ≤ 35 ∘C Flash point < 23 ∘C and initial boiling point > 35 ∘C Flash point ≥ 23 ∘C and ≤ 93 ∘C Flash point > 93 ∘C
Reactivity GHS: Explosives GHS Unstable GHS Division 1.1, 1.2, or 1.3 GHS Division 1.4 or 1.5 GHS Division 1.6 or GHS Category “Not Classified”
GHS: Self-reactive Substances GHS Type A or B GHS Type C or D GHS Type E or F GHS Type G or GHS Category “Not Classified”
GHS: Substances which on contact with water emit flammable gases GHS Category 1 GHS Category 2 GHS Category 3 GHS Category “Not Classified”
GHS: Oxidizing Gases GHS Type A or B GHS Type C or D GHS Type E or F GHS Type G or GHS Category “Not Classified”
GHS: Oxidizing Liquids and Solids GHS Category 1 GHS Category 2 GHS Category 3 GHS Category “Not Classified”
GHS: Organic Peroxides GHS Type A or B GHS Type C or D GHS Type E or F GHS Type G or GHS Category “Not Classified”
GHS: Self-Heating Substances Experimental data indicating persistent and very highly toxic degradation products. GHS Category 1 GHS Category 2 GHS Category “Not Classified”
GHS: Substances Corrosive to Metal GHS Category 1 GHS Category “Not Classified”

Appendix B: List Screening in SciveraLENS®: Roster of Lists Available  

 

The Enhesa team manages and maintains over 600 lists and sub lists and makes these available to SciveraLENS subscribers for instant screening. Our Toxicologists review hundreds of globally recognized lists that are created by regulatory agencies, organizations, NGOs, etc. We add the lists that matter most to our customers into SciveraLENS so that you can quickly see if any of your chemicals appear on a list of interest. In addition to monitoring these lists and making sure that you always have the most complete and up-to-date list when screening your chemicals, our Toxicologists also expand any lists that include chemical groups or families. This means that we identify all CAS numbers associated with a chemical group or family so that you get the most complete and accurate screening results. If anything changes on a list that you’re tracking, you’ll receive real-time alerts letting you know of the change. 

Our lists are separated into 8 different Types: 

  • Authoritative: Authoritative lists come from recognized experts that identify known hazards and are considered reliable and high confidence sources. 
  • Examples include: IARC – Cancer Monographs Carcinogen Groups, NTP-OHAT Lists 
  • Chemical Group: A chemical group refers to a classification of chemicals that share similar structural characteristics, functional groups, or properties. These groups are often used to organize substances for hazard assessment, regulatory purposes, or scientific study. Examples include halogens, phthalates, polycyclic aromatic hydrocarbons (PAHs), or per- and polyfluoroalkyl substances (PFAS). Grouping chemicals helps streamline evaluations by identifying shared risks, behaviors, or environmental impacts within the group. 
  • Examples include Aluminum, PFAS, Flame Retardants 
  • Informational or Inventory List: Informational or Inventory Lists catalog chemicals for reference purposes, offering details such as chemical names, structures, uses, and properties. They are not tied to regulatory or compliance requirements but serve as a resource for stakeholders to understand chemical characteristics or track inventory. 
  • Examples include: Canada DSL, The International Fragrance Association (IFRA) Transparency List 
  • Preferred List: Preferred lists identify chemicals or materials that meet specific safety, environmental, or performance criteria, making them favorable for use. These lists are often developed to promote safer and more sustainable alternatives in product design and manufacturing. 
  • Examples include: EPA Safer Chemical Ingredient List, ChemForward Safer Flame Retardants List 
  • Regulatory List: Regulatory lists are developed and maintained by government agencies or authoritative bodies to identify substances that are subject to legal or compliance requirements. These lists are enforceable and often specify restrictions, bans, or reporting obligations, ensuring adherence to regional or international laws. 
  • Examples include: California Proposition 65, ECHA, EU REACH, Oregon Health Authority, Washington State CHCC 
  • Restricted Substance List: Restricted Substance Lists (RSLs) identify chemicals that are limited or prohibited in specific products, industries, or regions. Typically developed by companies, industry groups, or organizations, these lists are designed to ensure compliance with regulatory requirements, align with sustainability goals, or meet customer demands. 
  • Examples include: Cradle to Cradle lists, Specific brand RSLs 
  • Screening List: Screening lists flag chemicals for preliminary assessment based on hazard, exposure, or regulatory status. They help prioritize substances for further evaluation or management, often serving as an initial step in risk assessment processes. 
  • Examples include: AOEC Asthmagens, Grandjean & Landrigan Neurotoxic Chemicals, Silent Spring Institute Mammary Carcinogens Reviews Database 
  • Watch List: Watch lists identify chemicals of emerging concern that may pose potential risks to health or the environment. While not yet subject to regulatory action, these substances are monitored closely for new scientific data or regulatory developments, enabling proactive management. 
  • Examples include: European Commission Restrictions Roadmap Under the Chemical Strategy for Sustainability European Green Deal, Scientific Committee on Consumer Safety (SCCS), International Living Future Institute – Living Building Challenge Watch List 

If you don’t see a list that you’re interested in, please let us know and we can work with you to add what you need. 

Lists Managed in SciveraLENS (March 27, 2025)  

 

Australia (AU) Government Department of Health and Aged Care (DHAC) Inventory of Industrial Chemicals (AIIC) 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Additional Category Reproductive Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Acute Dermal Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Acute Inhalation Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Acute Oral Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Aspiration Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Corrosive to Metals 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Eye Damage 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Flammable Gases 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Flammable Liquids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Flammable Solid 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Hazardous to the Aquatic Environment, Acute Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Hazardous to the Aquatic Environment, Long-Term Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Hazardous to the Ozone Layer 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Oxidizing Gases 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Oxidizing Liquids/Solids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Pyrophoric Liquids/Solids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Respiratory Sensitisation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Self-heating Substances and Mixture 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Skin Sensitisation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Specific Target Organ Toxicity, Repeated Exposure 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Specific Target Organ Toxicity, Single Exposure 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1 Substances Which, in Contact with Water, Emit Flammable Gases 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1A Carcinogenicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1A Reproductive Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1A Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1A Skin Sensitisation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1B Carcinogenicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1B Germ Cell Mutagenicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1B Reproductive Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1B Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1B Skin Sensitisation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 1C Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Acute Dermal Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Acute Inhalation Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Acute Oral Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Carcinogenicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Flammable Gases 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Flammable Liquids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Flammable Solid 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Germ Cell Mutagenicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Hazardous to the Aquatic Environment, Acute Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Hazardous to the Aquatic Environment, Long-Term Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Oxidizing Liquids/Solids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Reproductive Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Self-heating Substances and Mixture 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Specific Target Organ Toxicity, Repeated Exposure 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Specific Target Organ Toxicity, Single Exposure 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2 Substances Which, in Contact with Water, Emit Flammable Gases 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 2A Eye Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Acute Dermal Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Acute Inhalation Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Acute Oral Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Flammable Liquids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Hazardous to the Aquatic Environment, Acute Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Hazardous to the Aquatic Environment, Long-Term Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Oxidizing Liquids/Solids 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Skin Corrosion/Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Specific Target Organ Toxicity, Single Exposure; Narcotic Effects 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 3 Specific Target Organ Toxicity, Single Exposure; Respiratory Tract Irritation 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 4 Acute Inhalation Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 4 Acute Oral Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 4 Acute Toxicity 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Category 4 Hazardous to the Aquatic Environment, Long-Term Hazard 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) H200 Explosives 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) H201 Explosives 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) H203 Explosives 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type A Organic Peroxides 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type A Self-reactive Substances and Mixtures 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type B Self-reactive Substances and Mixtures 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type C Organic Peroxides 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type C Self-reactive Substances and Mixtures 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type D Organic Peroxides 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type D Self-reactive Substances and Mixtures 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type E Organic Peroxides 

Australia (AU) Safe Work Australia (SWA) GHS Classifications under the Work Health and Safety Act (WHS) Type F Organic Peroxides 

Australia (AU) Safe Work Australia (SWA) Prohibited Carcinogens under the Work Health and Safety Act 

Australia (AU) Safe Work Australia (SWA) Restricted Carcinogens under the Work Health and Safety Act 

Australia (AU) Safe Work Australia (SWA) Restricted Hazardous Chemicals under the Work Health and Safety Act 

Australia-GHS-Eye Damage/Irritation Category 2B 

Australia-GHS-Organic Peroxides-Type B 

Brazil (BR) National Health Surveillance Agency (ANVISA) Permitted Preservative Substances for Personal Care Products, Cosmetics, and Perfumes RDC 528/2021 

Brazil (BR) National Health Surveillance Agency (ANVISA) Prohibited Substances for Manufacturers and Importers of Personal Care Products, Cosmetics, and Perfumes RDC 529/2021 

Canada (CA) Canadian Food Inspection Agency (CFIA) Plant and Animal Health Strategy, List of Prescribed Deleterious Substances 

Canada (CA) Environment and Climate Change Canada (ECCC) Canadian Environmental Protection Act (CEPA) Environmental Registry Toxic Substances List (Schedule 1) 

Canada (CA) Environment and Climate Change Canada (ECCC) Canadian Environmental Protection Act 1999 Notice With Request to Certain Per- Polyfluoroalkyl Substances (PFAS) 

Canada (CA) Environment and Climate Change Canada (ECCC) Canadian Environmental Protection Act Virtual Elimination List (CEPA) 

Canada (CA) Environment and Climate Change Canada (ECCC) Domestic Substances List (DSL) Results for all Existing Substances 

Canada (CA) Environment and Climate Change Canada (ECCC) Domestic Substances List (DSL) Substances that meet human health categorization criteria 

Canada (CA) Environment and Climate Change Canada (ECCC) Domestic Substances List Substances that are Persistent, Bioaccumulative and Inherently Toxic to the environment (PBiT) 

Canada (CA) Environment and Climate Change Canada (ECCC) Environmental Emergency Regulations (SOR/2019-51 Part1) 

Canada (CA) Environment and Climate Change Canada (ECCC) Environmental Emergency Regulations (SOR/2019-51 Part2) 

Canada (CA) Health Canada (HC) Consumer Chemicals and Containers Regulations Substances of Special Concern 

Canada (CA) Health Canada (HC) Cosmetic Ingredient Hotlist Prohibited 

Canada (CA) Health Canada (HC) Cosmetic Ingredient Hotlist Restricted 

Canada (CA) Health Canada (HC) Quebec Workplace Hazardous Materials Information System (WHMIS) 

Chile (CL) Ministry of Health of Chile Managing Airborne Hazardous Substance Exposure in the Workplace (Decree 594 Article 61) 

Chile (CL) Ministry of the Environment (MMA) National Chemical Substances Inventory 

China (CN) Chongqing Municipal People’s Government (CQMPG) Catalogue of Controlled Hazardous Chemicals 

China (CN) Chongqing Municipal People’s Government (CQMPG) Catalogue of Prohibited Hazardous Chemicals 

China (CN) Chongqing Municipal People’s Government (CQMPG) Catalogue of Restricted Hazardous Chemicals 

China (CN) Ministry of Ecology and Environment of the People’s Republic of China (MEE) Inventory of Existing Chemical Substances 

China (CN) Ministry of Ecology and Environment of the People’s Republic of China (MEE) List of Controlled Ozone Depleting Substances 

China (CN) Ministry of Ecology and Environment of the People’s Republic of China (MEE) The List of Chemicals for Prioritized Control 

China (CN) Ministry of Ecology and Environment of the People’s Republic of China (MEE) The List of Key Controlled New Pollutants 

China (CN) Ministry of Emergency Management of the People’s Republic of China (MEM) Catalogue of Hazardous Chemicals 

China (CN) Ministry of Emergency Management of the People’s Republic of China (MEM) Catalogue of Specially Controlled Hazardous Chemicals 

China (CN) Ministry of Industry and Information Technology of the People’s Republic of China (MIIT) Restriction of Hazardous Substances in Electronic and Electrical Equipment (China RoHS) 

Denmark (DK) Danish Environmental Protection Agency (DEPA) List of Undesirable Substances 

European Union (EU) European Chemicals Agency (ECHA) Article 95 of the Biocidal Products Regulation (BPR) List 

European Union (EU) European Chemicals Agency (ECHA) Batteries and Waste Batteries Prohibitions and Labelling Regulation (EU) 2023/1542 Annexes I and VI 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Acute Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Aquatic Acute 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Aquatic Chronic 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Aspiration Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Eye Damage 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Respiratory Sensitization 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 STOT Repeat Exposure 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 STOT Single Exposure 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Skin Corrosion 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1 Skin Sensitization 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1A Carcinogenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1A Mutagenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1A Reproductive Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1A Skin Corrosion 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1A Skin Sensitization 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1B Carcinogenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1B Mutagenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1B Reproductive Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1B Skin Corrosion 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1B Skin Sensitization 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 1C Skin Corrosion 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Acute Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Aquatic Acute 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Aquatic Chronic 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Carcinogenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Eye Irritation 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Mutagenicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Reproductive Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 STOT Repeat Exposure 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 STOT Single Exposure 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 2 Skin Irritation 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 3 Acute Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 3 Aquatic Chronic 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 3 STOT Single Exposure 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 4 Acute Toxicity 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Category 4 Aquatic Chronic 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging (CLP Regulation) Lactation 

European Union (EU) European Chemicals Agency (ECHA) Classification, Labelling and Packaging of Substances and Mixtures (CLP) All Health, Environmental, Physical Harmonized Classifications 

European Union (EU) European Chemicals Agency (ECHA) Co-formulants not Accepted for Inclusion in Plant Protection Products (PPP) Regulation 1107/2009/EC Annex III 

European Union (EU) European Chemicals Agency (ECHA) Endocrine disruptor assessment list Environmental Health 

European Union (EU) European Chemicals Agency (ECHA) Endocrine disruptor assessment list Full 

European Union (EU) European Chemicals Agency (ECHA) Endocrine disruptor assessment list Human Health 

European Union (EU) European Chemicals Agency (ECHA) Endocrine disruptor assessment list Not Endocrine Disrupting 

European Union (EU) European Chemicals Agency (ECHA) Flame Retardant Strategy List 

European Union (EU) European Chemicals Agency (ECHA) PBT/vPvB assessments under the previous EU chemicals legislation 

European Union (EU) European Chemicals Agency (ECHA) Persistent Organic Pollutants (POPs) Regulation (EU) 2019/1021 (Including Annexes I, II, III, IV) 

European Union (EU) European Chemicals Agency (ECHA) Prior Informed Consent (PIC) Regulation Annex I 

European Union (EU) European Chemicals Agency (ECHA) Proposed REACH Restricted Dermal Sensitizers 

European Union (EU) European Chemicals Agency (ECHA) REACH Annex XIV SVHC Authorisation list 

European Union (EU) European Chemicals Agency (ECHA) REACH Annex XVII Substances restricted under REACH 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Carcinogenic (Article 57a) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Endocrine disrupting properties (Article 57(f) – environment) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Endocrine disrupting properties (Article 57(f) – human health) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Equivalent level of concern having probable serious effects to human health (Article 57f) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Equivalent level of concern having probable serious effects to the environment (Article 57f) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Mutagenic (Article 57b) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List PBT (Article 57d) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Respiratory sensitising properties (Article 57(f) – human health) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Specific target organ toxicity after repeated exposure (Article 57(f) – human health) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List Toxic for reproduction (Article 57c) 

European Union (EU) European Chemicals Agency (ECHA) REACH Substances of High Concern (EU SVHC) Candidate List vPvB (Article 57e) 

European Union (EU) European Chemicals Agency (ECHA) Recommended chemicals for EU REACH Annex XIV SVHC Authorisation list 

European Union (EU) European Chemicals Agency (ECHA) Registry of SVHC intentions until outcome-Intentions 

European Union (EU) European Chemicals Agency (ECHA) Submitted SVHC Intentions-Full 

European Union (EU) European Commission (EC) Conflict Minerals Regulation 

European Union (EU) European Commission (EC) Cosmetics Ingredients: Annex III List of Substances Restricted in Cosmetic Products 

European Union (EU) European Commission (EC) Cosmetics Ingredients: Annex IV List of Colorants Allowed in Cosmetic Products 

European Union (EU) European Commission (EC) Cosmetics Ingredients: Annex V List of Preservatives Allowed in Cosmetic Products 

European Union (EU) European Commission (EC) Cosmetics Ingredients: Annex VI List of UV Filters Allowed in Cosmetic Products 

European Union (EU) European Commission (EC) EU Ecolabel Restricted Substances List for Footwear 

European Union (EU) European Commission (EC) EU Ecolabel Restricted Substances List for Textile Products 

European Union (EU) European Commission (EC) Ecodesign Requirements for Electronic Displays Commission Regulation (EU) 2019/2021 Annex II 

European Union (EU) European Commission (EC) List of Prohibited Fragrance Ingredients under Annex II Regulation 1223/2009/EC 

European Union (EU) European Commission (EC) List of Prohibited Substances in All Cosmetic Products under Annex II Regulation 1223/2009/EC 

European Union (EU) European Commission (EC) List of Prohibited Substances in Hair Dye Products under Annex II Regulation 1223/2009/EC 

European Union (EU) European Commission (EC) Ozone depletion substances (ODS) 

European Union (EU) European Commission (EC) Pollutant Release and Transfer Register Regulation (EC) No 166/2006 Annex II Pollutants 

European Union (EU) European Commission (EC) Priority Substances Directive (Directive 2008/105/EC Annex II) 

European Union (EU) European Commission (EC) Prohibition of Mercury and Mercury Containing Products (Regulation 2017/852) 

European Union (EU) European Commission (EC) Restriction of Hazardous Substances Directive (RoHS) Restricted Substances 

European Union (EU) European Commission (EC) Restrictions Roadmap Under the Chemical Strategy for Sustainability Pool 0 European Green Deal 

European Union (EU) European Commission (EC) Restrictions Roadmap Under the Chemical Strategy for Sustainability Pool 1 European Green Deal 

European Union (EU) European Commission (EC) Restrictions Roadmap Under the Chemical Strategy for Sustainability Pool 2 European Green Deal 

European Union (EU) European Commission (EC) SEVESO-III Directive on the Control of Major Accident Hazards Involving Dangerous Substances Annex I Part 2 

European Union (EU) European Commission (EC) Toy Safety Directive 2009/48/EC Allergenic Fragrances (Banned List) 

European Union (EU) European Commission (EC) Toy Safety Directive 2009/48/EC Allergenic Fragrances (Labeling List) 

European Union (EU) European Commission (EC) Toy Safety Directive 2009/48/EC EN 71-3 Safety of toys Annex II Migration Limits on Metal 

European Union (EU) European Commission (EC) Waste from Electrical and Electronic Equipment WEEE Directive (Annex VII) 

European Union (EU) European Food Safety Authority (EFSA) Union List of Authorised Substances for Food Contact Materials 

European Union (EU) National Competent Authorities (NCAs) List of Substances Considered as Endocrine Disruptors – List III 

European Union (EU) National Competent Authorities (NCAs) Substances Identified as Endocrine Disruptors at EU Level – List I 

European Union (EU) National Competent Authorities (NCAs) Substances under Evaluation for Endocrine Disruption in EU Legislation – List II 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Final Opinions 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Fragrance Allergens Established contact allergens in humans 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Fragrance Allergens Established fragrance contact allergens of special concern (single chemicals only) 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Fragrance Allergens Fragrance substances categorised as established contact allergens in animals 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Fragrance Allergens Fragrance substances categorised as likely contact allergens by combination of evidence 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Fragrance Allergens Fragrance substances categorised as possible contact allergens 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Opinions being finalised 

European Union (EU) Scientific Committee on Consumer Safety (SCCS) Preliminary Opinions open for comments 

Germany (DE) Federal Environment Agency (UBA) Class 0 Substances, Non-Hazardous to Water 

Germany (DE) Federal Environment Agency (UBA) Class 1 Substances, Low Hazard to Water 

Germany (DE) Federal Environment Agency (UBA) Class 2 Substances, Hazardous to Water 

Germany (DE) Federal Environment Agency (UBA) Class 3 Substances, Severely Hazardous to Water 

Germany (DE) Federal Environment Agency (UBA) Substances Generally Hazardous to Water (AWG) 

Germany (DE) German Research Foundation (DFG) List of Substances in the MAK Classification for Germ Cell Mutagenicity 

Germany (DE) German Research Foundation (DFG) List of Substances in the MAK Classification for Pregnancy Risk Group 

Germany BAT Carcinogenic Substances Categories 1 

Germany BAT Carcinogenic Substances Categories 2 

Germany MAK Carcinogenic Substances Categories 1 

Germany MAK Carcinogenic Substances Categories 2 

Germany MAK Carcinogenic Substances Categories 4 

Germany MAK Carcinogenic Substances Categories 5 

Germany MAK Carcinogenic Substances Category 3 

Germany MAK Sensitizing Substances 

Indonesia (ID) National Agency of Drug and Food Control of Indonesia (BPOM) Appendix V, Not Permitted Chemicals in Cosmetics 

Indonesia (ID) National Agency of Drug and Food Control of Indonesia (BPOM) Food and Drug Administration Appendix I, Permitted Cosmetic Ingredients 

Indonesia (ID) National Agency of Drug and Food Control of Indonesia (BPOM) Food and Drug Administration Appendix II, Colouring Agents Permitted in Cosmetics 

Indonesia (ID) National Agency of Drug and Food Control of Indonesia (BPOM) Food and Drug Administration Appendix III, Preservatives Permitted in Cosmetics 

Indonesia (ID) National Agency of Drug and Food Control of Indonesia (BPOM) Food and Drug Administration Appendix IV, Sunscreen Ingredients Permitted in Cosmetics 

International (XE) Acer Restricted Substances 

International (XE) Adidas Policy for the Control and Monitoring of Hazardous Substances 

International (XE) Amazon AWS 

International (XE) Amazon Devices RSL 

International (XE) Amazon Private Brands 

International (XE) Amazon Robotics Additional Chemicals 

International (XE) Amazon Robotics Packaging Content Labelling (State-Level Regulations) 

International (XE) American Apparel & Footwear Association (AAFA) Restricted Substance List 

International (XE) Apparel and Footwear International RSL Management Group (AFIRM Group) Packaging Restricted Substances List 

International (XE) Apparel and Footwear International RSL Management Group (AFIRM Group) Restricted Substance List 

International (XE) Apple Regulated Substances Specification 069-0135-M Reportable Substances and Future Restriction in Products 

International (XE) Apple Regulated Substances Specification 069-0135-M Restricted Substances in Products 

International (XE) BlueSign Restricted Substance List 

International (XE) C&A Restricted Substance List (C&A specific requirements. See description to select additional lists) 

International (XE) ChemForward Safer Flame Retardants List 

International (XE) Clean Electronics Production Network (CEPN) Priority Chemicals List 

International (XE) Clean Production Action Chemical Footprint Project (CFP) Chemicals of High Concern (CoHCs) Reference List v3.0 

International (XE) Clean Production Action Standard for Food Service Ware 

International (XE) Conference of the Parties (COP) Stockholm Convention on Persistent Organic Pollutants (POPs) 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Biological and Environmentally Released Materials 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Children’s Products 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Cosmetics and Personal Care Products 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Footwear, Apparel, and Jewelry Products 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Formulated Consumer Products 

International (XE) Cradle to Cradle (C2C) V4.1 Additional Restrictions for Textile Materials 

International (XE) Credo Beauty Restricted Substance List 

International (XE) Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers (ETAD) Heavy Metal Limits Included in Annex 2 for Dyes Under Zero Discharge of Hazardous Chemicals – ZDHC Sublist 

International (XE) Enhesa Alkylphenols and Alkylphenol Ethoxylates (APEs) 

International (XE) Enhesa Aluminum 

International (XE) Enhesa Antimony 

International (XE) Enhesa Arsenic 

International (XE) Enhesa Barium 

International (XE) Enhesa Bisphenol A (BPA) Based Chemistries and Related Compounds 

International (XE) Enhesa Borates 

International (XE) Enhesa Brominated and Chlorinated Flame Retardants 

International (XE) Enhesa Cadmium 

International (XE) Enhesa Chromium 

International (XE) Enhesa Cobalt 

International (XE) Enhesa Copper 

International (XE) Enhesa Flame Retardants 

International (XE) Enhesa Fluorinated Greenhouse Gases 

International (XE) Enhesa Halogenated Diarylalkanes 

International (XE) Enhesa Heavy Metals 

International (XE) Enhesa Lead 

International (XE) Enhesa Mercury 

International (XE) Enhesa Nickel 

International (XE) Enhesa Nonylphenol and ethoxylates 

International (XE) Enhesa Octylphenols and ethoxylates 

International (XE) Enhesa PFOA and salts and esters 

International (XE) Enhesa Parabens 

International (XE) Enhesa Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) 

International (XE) Enhesa Perfluorooctane Sulfonate (PFOS) and related compounds 

International (XE) Enhesa Phthalates 

International (XE) Enhesa Polybrominated Diphenyl Ethers (PBDEs) 

International (XE) Enhesa Polychlorinated Biphenyls 

International (XE) Enhesa Polychlorinated Naphthalenes 

International (XE) Enhesa Polychorinated Terphenyls 

International (XE) Enhesa Polycyclic Aromatic Hydrocarbons 

International (XE) Enhesa Selenium 

International (XE) Enhesa Tin 

International (XE) Enhesa Tin Organic 

International (XE) Enhesa UV Stabilizers and Absorbers 

International (XE) Enhesa Volatile Organic Compounds (VOCs) 

International (XE) Environmental Defense Fund (EDF) Packaging Restricted Substance List 

International (XE) Food Packaging Forum (FPF) Food Contact Chemicals database (FCCdb) V 5.0 

International (XE) Food Packaging Forum (FPF) Food Contact Chemicals database V 5.0 Priority Substances List 

International (XE) Global Automotive Declarable Substance List (GADSL) Declarable Substances 

International (XE) Global Automotive Declarable Substance List (GADSL) Declarable/Prohibited Substances 

International (XE) Global Automotive Declarable Substance List (GADSL) Prohibited Substances 

International (XE) Global Organic Textile Standard (GOTS) Manual for the implementation of GOTS v7.1 

International (XE) Green Science Policy Institute (GSPI) Six Classes Antimicrobials 

International (XE) Green Science Policy Institute (GSPI) Six Classes Bisphenols and Phthalates 

International (XE) Green Science Policy Institute (GSPI) Six Classes Certain Metals 

International (XE) Green Science Policy Institute (GSPI) Six Classes Flame Retardants 

International (XE) Green Science Policy Institute (GSPI) Six Classes PFAS 

International (XE) Green Science Policy Institute (GSPI) Six Classes Some Solvents 

International (XE) Greenpeace’s Global Research on Potentially Hazardous Chemicals – GreenPeace 11 Full 

International (XE) H&M Group Chemical Restrictions Additional Requirements MRSL and RSL 

International (XE) H&M MRSL Combined Groups 1 and 2 

International (XE) H&M MRSL Group 1 

International (XE) H&M MRSL Group 2 

International (XE) H&M RSL Aerosol Dispensers 

International (XE) H&M RSL Apparel Accessories Footwear Home Interior Textile Products 

International (XE) H&M RSL Candles 

International (XE) H&M RSL Chemical Products 

International (XE) H&M RSL Combined 

International (XE) H&M RSL Cosmetic Products 

International (XE) H&M RSL Electrical and Electronic Products and Batteries 

International (XE) H&M RSL Food Contact Products 

International (XE) H&M RSL Hardline 

International (XE) H&M RSL Medical devices 

International (XE) H&M RSL Packaging 

International (XE) H&M RSL Toys 

International (XE) Healthier Hospitals Initiatives (HHI) Safer Chemicals Healthy Interiors Guidance 

International (XE) Healthy Building Network Priority Asthmagens 

International (XE) International Aerospace Environmental Group (IAEG) Aerospace and Defense Declarable Substances List 

International (XE) International Agency for Research on Cancer (IARC) Cancer Monographs Carcinogens Group 1 

International (XE) International Agency for Research on Cancer (IARC) Cancer Monographs Carcinogens Group 2A 

International (XE) International Agency for Research on Cancer (IARC) Cancer Monographs Carcinogens Group 2B 

International (XE) International Agency for Research on Cancer (IARC) Cancer Monographs Carcinogens Group 3 “not classifiable as to its carcinogenicity to humans” 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) All Chemicals by CAS RN (Not Enhea Expanded) 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) All Chemicals with 15 Chemical Groups 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) Carcinogenicity Health Concern 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) Endocrine Activity Health Concern 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) Mutagenicity Health Concern 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) PBT 

International (XE) International Chemical Secretariat (ChemSec) Substitute it Now List (SIN) Toxic to Reproduction 

International (XE) International Chemical Secretariat (ChemSec) The 32 to leave behind, high concern endocrine disrupting chemicals 

International (XE) International Fragrance Association (IFRA) Standards Prohibited Substances 

International (XE) International Fragrance Association (IFRA) Standards Restricted and Specified Substances 

International (XE) International Living Future Institute (ILFI) Living Building Challenge Watch List 

International (XE) International Living Future Institute (ILFI) Living Building Challenge Watch List (Not Enhesa Expanded) 

International (XE) International Living Future Institute (ILFI) Living Building Challenge Watch List: Priority for Red List Inclusion 

International (XE) International Living Future Institute (ILFI) Living Building Challenge Watch List: Priority for Red List Inclusion (Not Enhesa Expanded) 

International (XE) International Living Future Institute Living Building Red List 

International (XE) International Living Future Institute Living Building Red List (Enhesa Enhanced) 

International (XE) International Panel on Chemical Pollution (IPCP) San Antonio Statement on Brominated and Chlorinated Flame Retardants 

International (XE) Lancet Grandjean & Landrigan Neurotoxic Chemicals 

International (XE) Levi S & Co RSLUsage Banned 

International (XE) Levi Strauss & Co. (Levi’s) Product Safety by Design Framework for Restricted Substances List 

International (XE) Mind the Store The Ban the Bad Priority List 

International (XE) NextGen Integrated RSL for Food Packaging Materials 

International (XE) Nike Electronics RSL Full 

International (XE) Nike List Hazardous Air Pollutants 

International (XE) Nike List Volatile Organic Compounds 

International (XE) Nike Packaging Restricted Substances List 

International (XE) Nike Priority Chemicals for Formulation Cap 

International (XE) Nike Restricted Substance List for Toys 

International (XE) Nike Restricted Substances List Chemical Group Volatile Organic Compounds (VOCs) 

International (XE) Nike Restricted Substances List Core CAS RNs 

International (XE) OEKO-TEX Eco Passport Standard for Chemical Products Used in the Textile, Leather and Clothing Industries – Annex 6 

International (XE) Organisation for Economic Co-operation and Development (OECD) Per- and Polyfluoroalkyl Substances (PFAS) 

International (XE) Oslo and Paris Conventions for the Protection of the Marine Environment (OSPAR) Chemicals for Priority Action Part A 

International (XE) Oslo and Paris Conventions for the Protection of the Marine Environment (OSPAR) Commission Substances of Possible Concern 

International (XE) Oslo and Paris Conventions for the Protection of the Marine Environment (OSPAR) Priority Action List 

International (XE) Packaging Pilot Base RSL 

International (XE) Patagonia Restricted Substances List 

International (XE) Pattys Toxicology Boyes Neurotoxicants 2001 

International (XE) Perkins + Will Architects Precautionary List 

International (XE) Perkins + Will Architects Watch List 

International (XE) SC Johnson (SCJ) Potential Skin Allergens 

International (XE) Safer Chemicals Healthy Families The Hazardous 100+ List of Chemicals of High Concern 

International (XE) Sephora Global Clean at Sephora Formula Banned List EU 

International (XE) Sephora Public Chemicals Policy High-Priority Chemicals 

International (XE) Silent Spring Institute Mammary Carcinogens Reviews Database 

International (XE) Standard 100 by OEKO-TEX Appendix 5 individual substances for Appendix 4 

International (XE) Sustainable Textile & Leather Production (STeP) by OEKO-TEX 

International (XE) The Endocrine Disruption Exchange (TEDX) Potential Endocrine Disruptors 

International (XE) The International Fragrance Association (IFRA) Transparency List 

International (XE) Toxics in Packaging Clearinghouse (TPCH) Restricted Substances List 

International (XE) United Nations Environment Programme (UNEP) Rotterdam Convention Prior Informed Consent (PIC) Annex III Chemicals 

International (XE) United Nations Environment Programme (UNEP) The Montreal Protocol on Ozone-Depleting Substances (Including All Annexes) 

International (XE) Walmart High Priority Chemicals 

International (XE) World Health Organization (WHO) Active Ingredients Believed to Be Obsolete or Discontinued for Use as Pesticides 

International (XE) World Health Organization (WHO) Extremely Hazardous Pesticide Active Ingredients – Class Ia 

International (XE) World Health Organization (WHO) Gaseous or Volatile Fumigants Not Classified in the WHO Recommended Classification of Pesticides 

International (XE) World Health Organization (WHO) Highly Hazardous Pesticide Active Ingredients – Class Ib 

International (XE) World Health Organization (WHO) Moderately Hazardous Pesticide Active Ingredients – Class II 

International (XE) World Health Organization (WHO) Pesticide Active Ingredients Unlikely to Present Acute Hazard in Normal Use 

International (XE) World Health Organization (WHO) Slightly Hazardous Pesticide Active Ingredients – Class III 

International (XE) Zero Discharge of Hazardous Chemicals (ZDHC) MRSLV3.1 Chapter 1 Textile, Leather, and Polymers (CASRNs + Groups) 

International (XE) Zero Discharge of Hazardous Chemicals (ZDHC) MRSLV3.1 Chapter 2 Candidate List (CASRNs + Groups) 

International (XE) Zero Discharge of Hazardous Chemicals (ZDHC) MRSLV3.1 Chapter 3 Archived List 

International WELL Building Institute (IWBI) Building Materials Disallowed by the WELL Building Standard (Enhesa Expanded) 

Japan (JP) Electronics and Information Technology Industries Association (JEITA) Industrial Standards for Specific Chemicals in Electrical and Electronic Equipment (Japanese RoHS, also known as J-Moss) 

Japan (JP) Japan Society for Occupational Health (JSOH) List of Occupational Carcinogens 

Japan (JP) Japan Society for Occupational Health (JSOH) List of Occupational Sensitizers 

Japan (JP) Japan Society for Occupational Health (JSOH) List of Reproductive Toxicants 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Act on the Control of Household Products Containing Harmful Substances 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Carcinogenic Substances Category 1A under the Industrial Safety and Health Act (ISHA) 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Carcinogenic Substances Category 1B under the Industrial Safety and Health Act (ISHA) 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Chemical Substances Causing Skin Disorders under the Industrial Safety and Health Act (ISHA) 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Highly Mutagenic Substances under the Industrial Safety and Health Act (ISHA) 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Poisonous and Deleterious Substances Control Act 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Positive List of Additives in Food Apparatus, Containers, and Packaging – Table 2 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Securing the Quality, Efficacy, and Safety of Cosmetic Products under Pharmaceuticals and Medical Devices Act 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Substances Excluded from Organic Cyanide Compounds under the Poisonous and Deleterious Substances Control Act 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) Substances Subject to Risk Assessment under the Industrial Safety and Health Act (ISHA) 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Aspiration 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Dermal Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Dermal Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Flammable Liquids 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Reproductive Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Respiratory Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1A Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1A Dermal Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1A Reproductive Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1A Respiratory Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1A-1B Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1B Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1B Dermal Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1B Germ Cell Mutagenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1B Reproductive Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1B Respiratory Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Acute Inhalation Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Aspiration 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Dermal Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Flammable Liquids 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Germ Cell Mutagenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Reproductive Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2 Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2A Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2A-2B Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 2B Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 3 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 3 Acute Inhalation Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 3 Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 3 Dermal Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 4 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 4 Acute Inhalation Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 4 Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 5 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 5 Acute Inhalation Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 5 Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Acute Inhalation Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Acute Oral Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Carcinogenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Dermal Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Germ Cell Mutagenicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Reproductive Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Respiratory Sensitization 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Not Classified Serious Eye Damage/Eye Irritation 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) – Full 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Acute Dermal Toxicity 

Japan (JP) Ministry of Health, Labour and Welfare (MHLW) The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Category 1 Acute Inhalation Toxicity 

Japan (JP) Ministry of the Environment (MOEJ) Chemical Substances Control Law (CSCL) Class I Specified Chemical Substances 

Japan (JP) Ministry of the Environment (MOEJ) Chemical Substances Control Law (CSCL) Class II Specified Chemical Substances 

Japan (JP) Ministry of the Environment (MOEJ) Chemical Substances Control Law (CSCL) Monitoring Chemical Substances 

Japan (JP) Ministry of the Environment (MOEJ) Chemical Substances Control Law (CSCL) Priority Assessment Chemical Substances (PACSs) 

Japan (JP) Ministry of the Environment (MOEJ) Pollutant Release and Transfer Register Law (PRTR Act – Class Ⅰ specific substances) 

Japan (JP) Ministry of the Environment (MOEJ) Pollutant Release and Transfer Register Law (PRTR Act – Class Ⅰ) 

Japan (JP) Ministry of the Environment (MOEJ) Pollutant Release and Transfer Register Law (PRTR Act – Class ⅠⅠ) 

Japan (JP) Ministry of the Environment (MOEJ) Water Pollution Prevention Act 

Korea (KR) Ministry of Environment (MOE) Designation of Restricted and Prohibited Substances (Appendix 2 and 3 Restricted) 

Korea (KR) Ministry of Environment (MOE) Designation of Restricted and Prohibited Substances (Appendix 4 and 5 Prohibited) 

Korea (KR) South Korea’s National Institute of Environmental Research (NIER) GHS Classifications 

Korea (KR) South Korea’s National Institute of Environmental Research (NIER) Registration and Evaluation of Chemicals (K-REACH) 

Malaysia (MY) Department of Occupational Safety and Health (DOSH) Classification, Labeling and Safety Data Sheet of Hazardous Chemicals (GHS) 

N CoE VOCs 

New Zealand (NZ) New Zealand’s Environmental Protection Authority (NZ EPA) GHS Classifications 

Philippines (PH) Department of Environment and Natural Resources (DENR) Priority Chemicals List (PCL) 

Quebec Commission des normes, de l’équité, de la santé et de la sécurité du travail (CSST) Asthma Agents 

Southeast Asia (SEA) Association of Southeast Asian Nations (ASEAN) Cosmetic Directive, List of Permitted UV Filters in Cosmetic Products Annex VII 

Southeast Asia (SEA) Association of Southeast Asian Nations (ASEAN) Cosmetic Directive, List of Prohibited Substances Annex II Part 1 

Taiwan (Province of China) Ministry of Environment (MOENV) Existing Chemical Substances Subject to Standard Registration under TCCSCA Article 30 

Taiwan (Province of China) Ministry of Environment (MOENV) Toxic and Concerned Chemical Substances Control Act – TCCSCA 

Taiwan (Province of China) Occupational Safety and Health Administration (TOSHA) Occupational Safety and Health Administration (OSHA) GHS Classifications 

Thailand (TH) Department of Industrial Works (DIW) Existing Chemicals Inventory (TECI) 

Thailand (TH) Department of Industrial Works (DIW) Thai Ministerial Regulation on Hazardous Substances for Industrial Pollution Control – Hazardous Substances Act (HSA) 

United Arab Emirates (UAE) Saudi Standards, Metrology and Quality Organization (SASO) Restriction of Hazardous Substances in Electrical and Electronic Equipment (RoHS) 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) CERCLA Priority List of Hazardous Substances 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Carcinogenicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Dermal Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Developmental Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Endocrine Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Gastrointestinal Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Hematological Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Hepatotoxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Immunological Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Lymphoreticular Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Musculoskeletal Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Neurotoxicants 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Ocular Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Renal Toxicity 

United States of America (the) Agency for Toxic Substances and Disease Registry (ATSDR) Health Effects Associated with Respiratory Toxicity 

United States of America (the) American Conference of Governmental Industrial Hygienists (ACGIH) Biological Exposure Indices (BEIs) Notice of Intended Changes 2023 

United States of America (the) American Conference of Governmental Industrial Hygienists (ACGIH) Chemical Substances and Other Issues Under Study (TLV®-CS) 2023 

United States of America (the) Association of Occupational and Environmental Clinics (AOEC) Asthmagens 

United States of America (the) California Air Resources Board (CARB) Toxic Air Contaminants 

United States of America (the) California Department of Public Health (CDPH) Biomonitoring California Priority Chemicals 

United States of America (the) California Department of Public Health (CDPH) Reportable Ingredients List under the Safe Cosmetics Act 

United States of America (the) California Department of Toxic Substances Control (DTSC) Safer Consumer Products Candidate Chemicals Full Candidate Chemical List 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Cancer Potency Factors and Unit Risk Values Related to the Air Toxic Hot Spots Program 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Chemicals with California Office of Environmental Health Hazard Assessment Reference Exposure Levels (RELs) 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Proposition 65 Carcinogenicity 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Proposition 65 Chemicals with No Significant Risk Levels (NSRLs) Maximum Allowable Dose Levels (MADLs) 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Proposition 65 Developmental Toxicity 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Proposition 65 Reproductive Toxicity Female 

United States of America (the) California EPA Office of Environmental Health Hazard Assessment (OEHHA) Proposition 65 Reproductive Toxicity Male 

United States of America (the) California State Assembly Bill No. 312 Safe Cosmetics Act 

United States of America (the) California State Assembly Bill No. 496 Ingredients Banned in Cosmetics 

United States of America (the) California State Water Resources Control Board (SWRCB) California Priority Toxic Pollutants 

United States of America (the) California State Water Resources Control Board (SWRCB) Chemicals with Maxiumum Contaminant Levels (MCLs) 

United States of America (the) California State Water Resources Control Board (SWRCB) Chemicals with Notification Levels 

United States of America (the) Campaign for Safe Cosmetics’ Red List: TIER 1 

United States of America (the) Campaign for Safe Cosmetics’ Red List: TIER 1A 

United States of America (the) Campaign for Safe Cosmetics’ Red List: TIER 2 

United States of America (the) Campaign for Safe Cosmetics’ Red List: TIER 3 

United States of America (the) Consumer Product Safety Commission (CPSC) Strong Sensitizers 

United States of America (the) Consumer Product Safety Commission Supplemental Precautionary Labeling Required Substances 

United States of America (the) Cosmetic Ingredient Review (CIR) 2022–2025 Priority List with Ingredient Groups 

United States of America (the) Department of Homeland Security (DHS) Appendix A Chemicals of Interest – COI List 

United States of America (the) Environmental Protection Agency (US EPA) 20 high priority chemicals under TSCA 

United States of America (the) Environmental Protection Agency (US EPA) Active Ingredients Permitted in Exempted Minimum Risk Pesticide Products under FIFRA Law Part 152B Table 1 

United States of America (the) Environmental Protection Agency (US EPA) Certain Chemical Substances and Mixtures under TSCA Section 6 

United States of America (the) Environmental Protection Agency (US EPA) Chemical Action Plans (EPA Action) 

United States of America (the) Environmental Protection Agency (US EPA) Clean Water Act Priority Pollutants 

United States of America (the) Environmental Protection Agency (US EPA) Exempt VOCs 

United States of America (the) Environmental Protection Agency (US EPA) Extremely Hazardous Substances 

United States of America (the) Environmental Protection Agency (US EPA) Formaldehyde Standards for Composite Wood Products (Title VI) 

United States of America (the) Environmental Protection Agency (US EPA) Global Warming Potentials under Greenhouse Gas Reporting Program 40 CFR Part 98 

United States of America (the) Environmental Protection Agency (US EPA) Hazardous Air Pollutants (HAPs) 

United States of America (the) Environmental Protection Agency (US EPA) Inert Ingredients Permitted in Minimum Risk Pesticide Products under FIFRA Law Part 152B Table 2 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) 2005 Carcinogenic 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) 2005 Suggested Carcinogenic 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1986 A 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1986 B1 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1986 B2 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1986 C 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1996 Known/Likely 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1999 Carc 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1999 Likely Carcinogenic 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 1999 Suggested Carcinogen 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens (EPA C) 2005 Likely Carcinogenic 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Carcinogens All 

United States of America (the) Environmental Protection Agency (US EPA) Integrated Risk Information System (IRIS) Neurotoxicants 

United States of America (the) Environmental Protection Agency (US EPA) List of Extremely Hazardous Substances under the Emergency Planning and Community Right-to-Know Act 40 CFR Part 355 

United States of America (the) Environmental Protection Agency (US EPA) Ozone Depleting Substances (EPA-ODS) Class 1 

United States of America (the) Environmental Protection Agency (US EPA) Ozone Depleting Substances (EPA-ODS) Class 2 

United States of America (the) Environmental Protection Agency (US EPA) Persistent, Bioaccumulative, and Toxic (PBT) Chemicals under TSCA 

United States of America (the) Environmental Protection Agency (US EPA) Polycyclic Aromatic Hydrocarbons (PAHs) 

United States of America (the) Environmental Protection Agency (US EPA) Priority Persistent, bioaccumulative and toxic substances PBTs (National Waste Minimization Program (NWMP) Priority) 

United States of America (the) Environmental Protection Agency (US EPA) Proposed 20 Low-Priority Substances under the Toxic Substances Control Act (TSCA) 

United States of America (the) Environmental Protection Agency (US EPA) Reactivity Factors Associated with Volatile Organic Compound Emission under the Air Program 40 CFR Part 59 

United States of America (the) Environmental Protection Agency (US EPA) Resource Conservation and Recovery Act (RCRA) Hazardous Waste 

United States of America (the) Environmental Protection Agency (US EPA) Resource Conservation and Recovery Act (RCRA) Toxic Waste 

United States of America (the) Environmental Protection Agency (US EPA) Risk Management Program (RMP) Rule 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Antimicrobial Actives 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Chelating Agents 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Colorants 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Defoamers 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Emollients 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Enzymes and Enzyme Stabilizers 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Fragrances 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Full Green Circle 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Gray Square 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Half Green Circle 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Oxidants and Oxidant Stabilizers 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Polymers 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Preservatives and Antioxidants 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Processing Aids and Additives 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Skin Conditioning Agents 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Solvents 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Specialized Industrial Chemicals 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Surfactants 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Uncategorized 

United States of America (the) Environmental Protection Agency (US EPA) Safer Chemical Ingredient List Yellow Triangle 

United States of America (the) Environmental Protection Agency (US EPA) Tolerance Exemptions for Active and Inert Ingredients in Food-Contact Sanitizing Solutions under FFDCA Part 180.940 

United States of America (the) Environmental Protection Agency (US EPA) Tolerance Exemptions for Minimal Risk Active and Inert Ingredients under under FFDCA Part 180.950 

United States of America (the) Environmental Protection Agency (US EPA) Tolerance Exemptions for Polymers as Inert Ingredients in a Pesticide Chemical Formulation under FFDCA Part 180.960 

United States of America (the) Environmental Protection Agency (US EPA) Toxic Release Inventory (TRI) Program 

United States of America (the) Environmental Protection Agency (US EPA) Toxics Release Inventory Persistent, bioaccumulative and toxic substances (TRI PBT) 

United States of America (the) Environmental Protection Agency (US EPA) first 10 chemicals under TSCA 

United States of America (the) Environmental Protection Agency (US EPA) non-confidential Toxic Substances Control Act (TSCA) Chemical Substance Inventory 

United States of America (the) Environmental Protection Agency (US EPA) the Fifth Drinking Water Contaminate Candidate list (CCL 5) 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Cosmetics and Exempt from Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Cosmetics and Required for Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Devices and Exempt from Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Devices and Required for Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Drugs and Exempt from Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Drugs and Required for Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Food and Exempt from Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Approved for Use in Food and Required for Batch Certification 

United States of America (the) Food and Drug Administration (FDA) Color Additives Not Permitted for Any Use 

United States of America (the) Food and Drug Administration (FDA) Generally Regarded as Safe (GRAS) List of Food Additives 

United States of America (the) Food and Drug Administration (FDA) Indirect Additives Used in Food Contact Substances 

United States of America (the) Food and Drug Administration (FDA) Inventory of Environmental Impact Decisions for Food Contact Substance Notifications 

United States of America (the) Food and Drug Administration (FDA) Substances Determined Not to Be GRAS in Post-Market Evaluations 

United States of America (the) Green Building Council (USGBC) Substance to avoid to fulfill LEED Pilot Credit 54 Option 1 

United States of America (the) Maine Department of Environmental Protection (DEP) Chemicals of High Concern in Children’s Products 

United States of America (the) Maine Department of Environmental Protection (DEP) Safer Chemicals in Children’s Products Regulated Priority Chemicals 

United States of America (the) Maine State Legislature (MSL) Safe Cosmetics Act under Revised Statutes Title 22 Chapter 37 

United States of America (the) Massachusetts Toxics Use Reduction Institute (TURI) Toxics Use Reduction Act (TURA) PFAS categories 

United States of America (the) Minnesota Department of Health (MDH) Department of Health Chemicals of High Concern and Priority Chemicals 

United States of America (the) National Institute for Occupational Safety and Health (NIOSH) Occupational Carcinogens 

United States of America (the) National Oceanic and Atmospheric Administration (NOAA) Screening Quick Reference Tables for Inorganics in Sediments 

United States of America (the) National Oceanic and Atmospheric Administration (NOAA) Screening Quick Reference Tables for Inorganics in Soil 

United States of America (the) National Oceanic and Atmospheric Administration (NOAA) Screening Quick Reference Tables for Inorganics in Water 

United States of America (the) National Oceanic and Atmospheric Administration (NOAA) Screening Quick Reference Tables for Organics in Sediments 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Clear Evidence of Adverse Effects Developmental Toxicity 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Clear Evidence of Adverse Effects Reproductive Toxicity 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Limited Evidence of Adverse Effects Reproductive Toxicity 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Report on Carcinogens Known To Be Human Carcinogens 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Report on Carcinogens Reasonably Anticipated To Be Human Carcinogens 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Some Evidence of Adverse Effects Developmental Toxicity 

United States of America (the) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Some Evidence of Adverse Effects Reproductive Toxicity 

United States of America (the) New York State Senate Toxic Chemicals in Children’s Products under Environmental Conservation Law 

United States of America (the) Occupational Safety and Health Administration (OSHA) Carcinogens 

United States of America (the) Occupational Safety and Health Administration (OSHA) Limits for Air Contaminants 29 CFR 1910.1000 Table Z-1 

United States of America (the) Occupational Safety and Health Administration (OSHA) Limits for Air Contaminants 29 CFR 1910.1000 Table Z-2 

United States of America (the) Occupational Safety and Health Administration (OSHA) Limits for Air Contaminants 29 CFR 1910.1000 Table Z-3 

United States of America (the) Occupational Safety and Health Administration (OSHA) List of Highly Hazardous Chemicals, Toxics and Reactives 29 CFR 1910.119 Appendix A 

United States of America (the) Oregon Department of Environmental Quality (DEQ) Priority Persistent Pollutants (P3) List 

United States of America (the) Oregon Health Authority (OHA) High priority chemicals of concern to children’s health 

United States of America (the) United States of America (the) Food and Drug Administration (FDA) Antimicrobials Banned in Antiseptic Washes 

United States of America (the) Vermont Department of Health (VDH) Chemicals of High Concern to Children 

United States of America (the) Washington State Department of Ecology (Ecology) Chapter 173-339 WAC – Cosmetic Products Restrictions (Formaldehyde in Cosmetics) 

United States of America (the) Washington State Department of Ecology (Ecology) Chemicals of High Concern to Children (CCHC) 

United States of America (the) Washington State Department of Ecology (Ecology) Chemicals of High Concern to Children (CCHC) (Enhesa Expanded) 

United States of America (the) Washington State Department of Ecology (Ecology) PBT Metals of Concern 

United States of America (the) Washington State Department of Ecology (Ecology), Persistent, Bioaccumulative, and Toxic Substances 

United States of America (the)National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) Limited Evidence of Adverse Effect Developental Toxicity 

United States of American (the) Environmental Protection Agency (US EPA) Priority Persistent, bioaccumulative and toxic substances PBTs 

Viet Nam (VN) Chemicals Agency Law on Management of Chemicals: Annex 2 List of Restricted Substances 

Viet Nam (VN) Vietnam Chemicals Agency (VCA) National Chemical Inventory